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KMID : 0613820100200111675
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Journal of Life Science
2010 Volume.20 No. 11 p.1675 ~ p.1682
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Physiological Activities of Hot Water Extracts from Ecklonia cava Kjellman
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Cho Eun-Kyung
Choi Young-Ju
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Abstract
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The biological activity of hot water extract from Ecklonia cava Kjellman (ECE) was investigated to assess antioxidative, anti-skin aging, and nitrite scavenging abilities, as well as alcohol metabolizing activities. Antioxidant activity of ECE was measured by using 2,2-diphenyl-1-picryl-hydrazyl (DPPH) radical scavenging activity and superoxide dismutase (SOD)-like activity. DPPH radical scavenging activity and SOD-like activity of ECE increased in a remarkably dose-dependent manner, and were about 91.4% and 75% at 1 ㎎/ml, respectively. The xanthine oxidase inhibitory activity was indicated to be about 70% at 1 ㎎/ml of ECE. Nitrite scavenging ability of ECE showed to be 93.6% at 1 ㎎/ml and pH 1.2. The influence of ECE on alcohol metabolism was demonstrated through the generating activity of reduced-nicotinamide adenine dinucleotide (NADH) by alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH). The facilitating rate of ADH and ALDH activity by ECE was 167.2% and 334% at 10 ㎎/ml, respectively. In addition, tyrosinase and elastase inhibitory activities of ECE were 58% and 72% at 10 ㎎/ml, respectively. These results indicated that ECE has valuable biological attributes owing to its antioxidant, nitrite scavenging, alcohol metabolizing, and elastase and tyrosinase inhibitory activities.
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KEYWORD
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Hot water extract, Ecklonia cava, elastase inhibitory activity, nitrite scavening activity, alcohol metabolizing activity
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